PCOS: 5 Ways to Lose the Weight & Insulin Resistance

Let's discuss new science about how to lose weight and improve metabolic health.

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-------------------------Time Stamps-----------------------

0:00 Intro
0:04 PCOS (polycystic ovarian syndrome) is about 1 in 5 of women of childbearing age.
0:26 The root cause of PCOS is poor metabolic health.
1:54 Ovaries hyper secrete androgens that are linked with challenges within the ovaries and the formation of water-forming cysts.
2:39 Hormonal birth control is frequently prescribed to increase sex hormone binding globulin and neutralize the elevated androgens.
4:04 Some cytochrome P450 enzymes are involved in the formation of steroid-like hormones, like testosterone.
5:04 Insulin and IGF-1 increase the activity of a cytochrome P450 enzyme called CYP17A1, which then increases testosterone, dihydrotestosterone, and DHEA within the ovaries.
6:36 Excessive levels of androgens cause hair loss, infertility, lack of ovulation, and cause the formation of water forming cysts within the ovaries.
8:24 Autoimmunity often co-occurs with PCOS.
8:44 Deliberate cold exposure helps metabolic health by stimulating brown and beige fat cells.
9:54 Metabolic health increases the activity of enzymes that create hormones. It does the inverse in men and women.
10:04 Men’s poor metabolic health drives the formation of extra estrogen.
10:14 Women’s poor metabolic health drives the formation of extra testosterone.
12:44 97% of obese women have PCOS. 65% of non-obese women have PCOS.
13:14 Fat cells secrete hormones, called adipocytokines. One of these is leptin.
13:54 Leptin decreases activity of T-regulatory cells that help to prevent autoimmunity.
16:04 Belly fat cells convert androgens into estrogens. This is impacted by insulin.
18:14 Nutrition and exercise are fundamental ways to address poor metabolic health.
18:24 A ketogenic or low carb diet is helpful because it manages blood sugar and insulin, and ketones have immune signaling properties.
19:24 Intermittent fasting can support glycemic variability and improve insulin sensitivity.
19:46 Time restricted feeding with a 16 or 18 hour fast is also helpful for longevity, burning fat, and supporting metabolic health.
20:14 Poor sleep exacerbates insulin resistance. Tape your mouth shut when you sleep.
21:24 Resistance training decreases androgens in women with PCOS. All exercise supports underlying metabolic dysfunction.
22:24 Magnesium is helpful for supporting insulin sensitivity.
23:15 Myoinositol and inositol makes ovaries more sensitive to insulin, preventing the increase in androgens.
24:04 Vitamin D is involved in blood sugar regulation, immune health, and sleep quality.
24:19 Gut health is important to metabolic health. Eat real food and ferments.
24:54 Berberine hydrochloride, 500 mg 1 to 3 times per day, is a natural Metformin.
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