New insights on GLP-1 agonists—Ozempic, Wegovy, Mounjaro, and more (AMA 64 sneak peek)



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In this “Ask Me Anything” (AMA) episode, Peter dives back into the increasingly popular topic of GLP-1 agonists, such as Ozempic & Mounjaro, which have garnered widespread attention for their ability to promote weight loss. Peter covers the latest findings in this rapidly evolving landscape, including new insights into their long-term efficacy, side effects, & what happens when the drug is discontinued. Peter also explores their impact on body composition & how resistance training interacts with these treatments. Additionally, he compares different GLP-1 receptor agonists & discusses promising new drugs in the pipeline. Finally, Peter addresses questions about the role of compounding pharmacies in the GLP-1 agonist market, compares oral vs. injectable options, & provides key considerations for anyone deciding whether to use a GLP-1 agonist for weight loss.

We discuss:
00:09 - The rapidly evolving landscape of GLP-1 agonists
5:14 - The mechanism of GLP-1 agonists, origin as diabetes treatments, & how they evolved into weight-loss drugs
09:08 - Overview of new data & open questions related to the benefits & risks of GLP-1 agonists
16:19 - New insights into the long-term safety of GLP-1 agonists & side effects

In the full episode, we also discuss:
The long-term efficacy of GLP-1 agonists, financial barriers, & more;
The mechanisms behind GLP-1 agonists' ability to promote weight loss;
New data on body weight changes after discontinuing the drug;
Effects of GLP-1 agonists on lean mass & body composition, & the role of protein & resistance training in preserving muscle;
Semaglutide vs. tirzepatide;
How compounding pharmacies affect availability of GLP-1 drugs & the available formulations;
How oral formulations of GLP-1 drugs compare to injectable formulations;
How sublingual (under tongue) formulations of GLP-1 drugs compare to injectable formulations;
Guidance for using compounding pharmacies to purchase GLP-1 agonists;
Data on retatrutide—a promising new triple receptor agonist in the pipeline;
Can GLP-1 agonists be beneficial for sleep apnea & immune function?;
Potential neuroprotective benefits of GLP-1 agonists: impact on dementia risk;
Exploring why GLP-1 agonists may reduce the risk of cancer, kidney disease, & cardiovascular disease;
How GLP-1 agonists might boost fertility in women;
Early indications that GLP-1 agonists may help treat substance abuse disorders;
Potential health risks of GLP-1 agonists: addressing thyroid cancer concerns & the unknowns due to lack of data;
Examining the potential link between GLP-1 agonists & increased depression or suicidal ideation;
Major remaining questions: the effects of cyclic use, rebound appetite, impact on adolescents' development, & more;
Key considerations when deciding whether to use a GLP-1 agonist for weight loss;

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Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan & simultaneously improving their healthspan.

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