Impact of Covid-19 on Management of Patients With Metastatic Melanoma | Oncotarget

Oncotarget published this trending research paper in Volume 13, entitled, “Impact of Covid-19 on the management of patients with metastatic melanoma" by the researchers from the Department of Dermatology, University Hospital Zurich (USZ), Zurich 8091, Switzerland; Faculty of Medicine, University of Zurich (UZH), Zurich 8032, Switzerland; Institute for Biomedical Engineering, ETH Zurich, Zurich 8092, Switzerland.
#openaccess #covid19 #melanoma #covid #coronavirus #sars #immunotherapy #targetedtherapy #research #researchpaper #peerreview #openscience #cancertherapy

DOI - https://doi.org/10.18632/oncotarget.28333

Correspondence to - Michèle Welti - [email protected]

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Keywords - metastatic melanoma, Covid-19, Sars-CoV-2, immunotherapy, targeted therapy


The Covid-19 pandemic created new uncertainties in the management of metastatic melanoma patients. In particular, the impact of immunotherapy, targeted therapy, or chemotherapy on the risk of Sars-CoV-2 infection and severity was debated. In this study, we analyzed all patients with metastatic melanoma receiving therapy who developed Covid-19 between February 2020 and February 2022. We retrospectively collected demographic data, cancer-specific parameters, melanoma treatment regimen, comorbidities and Covid-19-specific parameters in these patients. Of the 350 patients with metastatic melanoma, 25 had Covid-19. The median age at the time of Covid-19 diagnosis was 66 years (range 36–86), 10 patients were female, and 15 patients were male. The treatment regimen during infection was immunotherapy in 12 cases, followed by targeted therapy (n = 8), chemotherapy (n = 2), and TVEC injections, follow-up and palliative therapy in 1 case each. The severity was mild in 17 patients and 8 had a moderate to critical course. Patients with a severe Covid-19 course were often older and had more comorbidities than patients with a mild infection. Many of the patients had a mild Covid-19 course despite having metastatic melanoma and systemic therapy. We therefore recommend continuing systemic therapy whenever possible, even in such exceptional situations as the Covid-19 pandemic.

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